Oxidation of Cholesterol, 3beta-Hydroxy-5-pregnen-20-one and 3beta-Hydroxy-5-androsten-17-one by Rat Liver Microsomes
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چکیده
منابع مشابه
Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems.
We have previously demonstrated that the rat brain contains three unconjugated bile acids, and chenodeoxycholic acid (CDCA) is the most abundantly present in a tight protein binding form. The ratio of CDCA to the other acids in rat brain tissue was significantly higher than the ratio in the peripheral blood, indicating a contribution from either a specific uptake mechanism or a biosynthetic pat...
متن کاملThe interaction of mammary glucose 6-phosphate dehydrogenase with pyridine nucleotides and 3beta-hydroxyandrost-5-en-17-one.
Glucose g-phosphate dehydrogenase was first described in yeast by Warburg and Christian (l), who showed that nicotinamide adenine dinucleotide phosphate was the specific coenzyme. The enzyme was later prepared from liver and again shown to be specific for the same coenzyme (2). Subsequent preparations (see Cheldelin (3)) from various microbial sources have included two which react with both nic...
متن کاملChemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone.
Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of human prostate cancer. Studies were performed to compare the androgenicity of DHEA and a fluorinated DHEA analog, 16alpha-fluoro-5-androsten-17-one (fluasterone), and to determine the chemopreventive a...
متن کاملDietary 5-campestenone (campest-5-en-3-one) enhances fatty acid oxidation in perfused rat liver.
The effect of dietary 5-campestenone (campest-5-en-3-one), a chemical modification product of a naturally-occurring plant sterol, campesterol, on lipid metabolism was examined using a rat liver perfusion system. Male Sprague-Dawley rats weighing about 140 g were fed a diet supplemented with or without 0.2% 5-campestenone for 14 d. 5-Campestenone feeding resulted in a marked reduction in the con...
متن کامل5'-Nucleotidase of rat liver microsomes.
Recent observations from this laboratory have revealed that there is an alteration in the kinetic properties of microsomal glucose 6-phosphatase in the livers of diabetic rats (1, Z), in addition to the’well established increase in total activity (3, 4). Since the kinetic differences between the normal and the diabetic enzyme disappeared upon disruption of the microsomes (Z), it seemed possible...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1971
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1971.tb01441.x